IS CBD SAFE FOR MY DOG?
You love your dog and you are new to CBD. What is this thing you keep hearing your pet parent friends keep talking about? Here is some information to help you out:
CBD binds to the cannabinoid receptors to produce homeostasis (balance) in the body. It's used to treat anxiety, pain, mood, seizures, and many other health conditions in humans. Like humans, dogs have an endocannabinoid system that works the same way as the human system, and they can benefit from CBD like humans.
THC vs. CBD for Dogs
(from the petmd.com article)
CBD is one of over 80 different chemical compounds called “cannabinoids” that have been derived from the cannabis (marijuana) plant. Unlike tetrahydrocannabinol (THC), perhaps the most famous cannabinoid, CBD is not psychoactive.
Instead, CBD shares important metabolic pathways with a class of drugs called NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen and Rimadyl. These pathways control many processes in the body, from inflammatory responses to blood clotting.
Do not give dogs straight marijuana or any product containing tetrahydrocannabinol (THC), the primary psychoactive component of marijuana. There is simply not enough research to justify the use.
CBD-based products, however, may help improve your dog's quality of life when used in conjunction with other therapies.
Why Use CBD for Dogs?
CBD is often mentioned as a useful therapy for a variety of conditions, including pain management, arthritis, anxiety, seizures, and even cancer. Although the use of CBD in treating each of these conditions is under-researched, there are varying levels of scientific evidence for each scenario.
Because CBD shares metabolic pathways with anti-inflammatory drugs, it makes sense that it would help with certain inflammatory conditions (anything that ends with -itis is an inflammatory condition).
Osteoarthritis, often abbreviated as arthritis, is one of the most common inflammatory conditions in dogs.
One in four dogs will be diagnosed with arthritis in their lifetime, and by some estimates, as many as 60% of dogs exhibit some degree of the disease.
Research has shown that CBD can provide substantial pain relief in dogs with arthritis when given twice daily at appropriate doses.
In theory, the anti-inflammatory benefit seen in arthritic dogs could also be seen in dogs with other types of inflammatory pain, especially back pain from intervertebral disc disease (IVDD).
Preliminary studies in people have shown that combo products containing both CBD and THC are more beneficial for pain relief than when either drug is given alone. But no such research has been done on dogs, so THC should not be given to them.
Seizures are probably the most-studied application of CBD in people, but limited research exists for pets. In dogs, seizures can be caused by a vast number of underlying conditions.
With regards to idiopathic epilepsy specifically, there is some research that suggests that CBD could be useful in reducing seizure frequency in these dogs. However, these benefits are only seen with dogs that are given traditional anti-seizure medications at the same time.
Like seizures, the term “cancer” is an umbrella term that refers to an extremely diverse set of specific diseases, each with their own set of beneficial treatments.
In people, CBD has been studied for possible use in cancer patients, both to treat the tumor(s) directly, as well as to treat the secondary symptoms of cancer and chemotherapy. Very limited research has been done on the use of CBD for dogs with cancer.
However, the anti-nausea effects of CBD seen in people who undergo chemotherapy have also been documented in rats and ferrets, suggesting that dogs receiving chemotherapy may benefit from CBD treatment.
Perhaps the biggest misconception is that CBD is useful in managing a dog’s anxiety. In theory, it is possible that CBD, by reducing pain and inflammation, could indirectly reduce anxiety caused by pain or inflammation.
But because CBD is not psychoactive, it is unlikely that CBD has the ability to directly treat canine anxiety in the way that Prozac and other medications do. The use of CBD for anxiety in dogs, as with most conditions, requires substantially more research.
Potential Risks of CBD for Dogs
Overall, CBD itself seems to be incredibly safe in dogs and cats. However, numerous scientific papers have found that when given at the recommended doses, CBD does cause an elevation in an important liver value on bloodwork called alkaline phosphatase (ALP).
We are not yet sure whether the elevation of this liver value has any medical significance. It could signify that CBD causes irritation or damage to the liver. Alternatively, it could be an artificial finding in which the drug interferes with the way the lab measures the liver value.
Anecdotal reports do exist of dogs becoming somewhat sleepy or sedate if they receive extremely large doses of CBD, but those effects appear to resolve on their own with time.
CBD doesn’t appear to have any drug interactions when it’s given to a dog that’s on an anti-inflammatory drug like Rimadyl.
Because there is a theoretical risk of drug interaction, as with any medication, you should consult your veterinarian first before treating your dog with CBD.